Mankind's scientists complete the sequencing of the human genome, allowing for significant advances in genetic research.
By the end of the early 22nd Century, Mars becomes the first human colony world to be terraformed. It is given an atmosphere and its deserts are transformed into fertile soil. Mars is then settled by industrial cartels and their workforces, quickly growing into the first human Hive World in subsequent centuries.
Scientific advances of the third and subsequent millennia bring some basic knowledge of the Warp to humans.
Colonisation of the Solar System
Humanity begins to colonise the Solar System using conventional sub-light spacecraft. Colonies are established on Mars, and on the moons of Jupiter, Saturn, and Neptune. This is the full extent of mankind's domains across the Milky Way Galaxy until the 15th Millennium.
Humanity Colonises the Galaxy
Humanity uses Ohnyl Cylinders (O'Neill Space Colonies) to spread beyond its own home solar system to local habitable planets in other nearby star systems. However, such early interstellar colonies would not reestablish contact with Terra until millennia later.
Realm of Chaos: The Lost and the Damned (2nd Editon)